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Overdose of benzodiazepines together with other CNS depressants (which includes alcohol) could be lethal and may be intently monitored.

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Sternbach's approach commenced with two-amino-5-chlorobenzophenone, which undergoes cyclocondensation with glycine ethyl ester hydrochloride to construct the benzodiazepine core. This Main is subsequently alkylated in the nitrogen during the 1-posture employing dimethyl sulfate during the presence of sodium methoxide and methanol below reflux situations.

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